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443 studies · 157 with full dosimetry

Skin and wrinkles research

Collagen density, fine lines, tone and texture.

Sorted newest first. The dose column is what the study actually delivered, which is the number to compare a device against. Rows without a recorded dose are excluded here because they cannot be matched to a protocol.

StudyYearλ nmDose J/cm²Sessions
Low-Level Laser Therapy as an Effective Intervention for Facial Pigmentation: A Case Report of Ephelides and L
Shurrab & Alzghayar · Case Rep Dermatol Med
20256605.6—
Blue LED photobiomodulation in the prevention of radiodermatitis in breast cancer survivors: a clinical trial
Pivetta · Support Care Cancer
202547018.6—
Photobiomodulation therapy for enhanced wound and Scar healing: visual and statistical evaluation
Shurrab & Aoida · Lasers Med Sci
20256603.72
Clinical Application of a New Near-Infrared Light-Emitting Diode with Broader Spectrum for Skin Rejuvenation a
Kim · Aesthet Plast Surg
2025600, 10001.4560
Efficacy and safety of 570/590 Nm yellow light combined with red light and infrared LED in treating facial ski
Yi · Lasers Med Sci
2025570, 590, 620, 8506.391
Red light promotes dermis-epidermis remodeling via TGFβ and AKT-mediated collagen dynamics in naturally aging
Chang · Zool Res
2025400, 520, 525, 630, 635, 800828
Role of photobiomodulation application frequency in facial rejuvenation: randomized, sham-controlled, double-b
Bragato · Lasers Med Sci
20256608.052
Efficacy of adjuvant Photobiomodulation therapy in recurrent herpes labialis, a randomized clinical trial stud
Seyyedi · Photodiagnosis Photodyn Ther
20249404—
Efficacy of photobiomodulation therapy in recurrent herpes labialis management: a randomized controlled trial
Al-Hallak · Clin Oral Investig
20246504.7—
Photobiomodulation Using 830 nm Lighting-Emitting Diode Inhibits Melanogenesis via FOXO3a in Human Melanocyte
Dan · Pigment Cell Melanoma Res
20248305—
Efficacy of Nd:YAG Laser 1064-nm in the Treatment of Onychomycosis
Kiran · J Coll Physicians Surg Pak
2024106440—
Outstanding user reported satisfaction for light emitting diodes under-eye rejuvenation
Wang · Arch Dermatol Res
2024633, 830183
Clinical Validation of Face-Fit Surface-Lighting Micro Light-Emitting Diode Mask for Skin Anti-Aging Treatment
Kim · Adv Mater
20246271.0824
Low-level laser therapy for skin rejuvenation: A safe and effective solution baked by data and visual evidence
Shurrab & Alzghayar · J Cosmet Dermatol
2024660312
Exploring the Safety and Efficacy of Organic Light-Emitting Diode in Skin Rejuvenation and Wound Healing
Lee · Yonsei Med J
2024625, 628, 6306—
Full-body blue light irradiation as treatment for atopic dermatitis: a randomized sham-controlled clinical tri
Buhl · J Dtsch Dermatol Ges
2023415, 4503624
Photobiomodulation Therapy for Multiple Painful Fixed Drug Eruptions: The First Case Report
Palma · J Lasers Med Sci
2023660257
Reverse skin aging signs by red light photobiomodulation
Couturaud · Skin Res Technol
202363015.62
Photobiomodulation Reduces Periocular Wrinkle Volume by 30%: A Randomized Controlled Trial
Mota · Photobiomodul Photomed Laser Surg
2023590, 6603.8410
Clinical and molecular change induced by repeated low-dose visible light exposure in both light-skinned and da
Kim · Photodermatol Photoimmunol Photomed
2022400, 7001204
Photobiomodulation for Preventive Therapy of Recurrent Herpes Labialis: A 2-Year In Vivo Randomized Controlled
Zanella · Photobiomodul Photomed Laser Surg
202280811.1115
590 nm LED Irradiation Improved Erythema through Inhibiting Angiogenesis of Human Microvascular Endothelial Ce
Dai · Cells
2022590208
The Efficacy of Photobiomodulation Therapy in Improving Tissue Resilience and Healing of Radiation Skin Damage
Mosca · Photonics
2022660, 88020—
Irradiation with 590-nm yellow light-emitting diode light attenuates oxidative stress and modulates UVB induce
Hong · Exp Dermatol
202259034.2—
The efficacy of blue light versus the combination of blue and red light therapy in the treatment of acne vulga
Kharazi · Photodermatol Photoimmunol Photomed
2021415, 633488
Effect of low-level laser intervention on dermatitis symptoms and cytokine changes in DNCB-induced atopy mouse
Kim · Exp Ther Med
2021650214
Transcriptome analysis of human dermal fibroblasts following red light phototherapy
Austin · Sci Rep
2021633320—
Red light emitting diode as an adjuvant treatment for epidermal growth factor receptor inhibitors-induced paro
Jornsamer · J Dermatolog Treat
20216331262
Light emitting diode-red light for reduction of post-surgical scarring: Results from a dose-ranging, split-fac
Kurtti · J Biophotonics
20216331609
Antifibrotic effects of Hypocrellin A combined with LED red light irradiation on keloid fibroblasts by countera
Niu · Photodiagnosis Photodyn Ther
20216303—
Low-Level Red Plus Near Infrared Lights Combination Induces Expressions of Collagen and Elastin in Human Skin
Li · Int J Cosmet Sci
2021640, 8300.3—
Low-Level Laser Therapy for Diabetic Dermopathy in Patients With Type 2 Diabetes: A Placebo-Controlled Pilot S
Abdelhalim · J Lasers Med Sci
20206322.512
Role of low-level laser therapy in post-herpetic neuralgia: a pilot study.
Mukhtar · Lasers Med Sci
20206503.616
Impact of 970 Nm Photobiomodulation Therapy on Wound Healing in Cellular Models of Hidradenitis Suppurativa
Zupin · Lasers Med Sci
202097030—
Experimental Study on Blue Light Interaction with Human Keloid-Derived Fibroblasts
Magni · Biomedicines
2020410, 4303.43—
Synergistic effects of using novel home-use 660- and 850-nm light-emitting diode mask in combination with hyal
Kim · J Cosmet Dermatol
2020660, 8501.8928
Polysaccharide-rich Hydrogel Formulation Combined With Photobiomodulation Repairs UV-induced Photodamage in Mi
Neves · Wound Repair Regen
202066040—
Proteomic Analysis Reveals Anti-Fibrotic Effects of Blue Light Photobiomodulation on Fibroblasts.
Chang · Lasers Surg Med
20194634—
MicroRNA expression analysis of human skin fibroblasts treated with high-fluence light-emitting diode-red ligh
Mamalis · J Biophotonics
2019633320—
A Randomized, Double-Blind, Controlled Trial Evaluating the Efficacy of Nd:YAG 1064 nm Short-Pulse Laser Compa
Sabbah · J Cutan Med Surg
2019106463
Feasibility of photobiomodulation therapy for the prevention of radiodermatitis: a single-institution pilot st
Park · Lasers Med Sci
2019590, 8306018
In vitro effect of low-level laser therapy on the proliferative, apoptosis modulation, and oxi-inflammatory ma
Maldaner · Lasers Med Sci
20196603—
Q-switched 1064-nm dymium-doped yttrium aluminum garnet laser irradiation induces skin collagen synthesis by s
Yang · Lasers Med Sci
201910640.5—
Transcriptomic analysis of human dermal fibroblast cells reveals potential mechanisms underlying the protectiv
Hyun Soo · J Dermatol Sci
201966060—
Physiological Doses of Red Light Induce IL-4 Release in Cocultures between Human Keratinocytes and Immune Cell
Leong · Photochem Photobiol
2018380, 505, 6271—
Adipose-derived mesenchymal stem cells treatments for fibroblasts of fibrotic scar via downregulating TGF-β1 a
Han · Lasers Med Sci
2018635, 65543
High-Fluence Light-Emitting Diode-Generated Red Light Modulates the Transforming Growth Factor-Beta Pathway in
Mamalis & Jagdeo · Dermatol Surg
2018633320—
Light-emitting diode 585nm photomodulation inhibiting melanin synthesis and inducing autophagy in human melano
Chen · J Dermatol Sci
20185855—
The Management of Melasma on Skin Types V and VI Using Light Emitting Diode Treatment
Mpofana & Abrahamse · Photomed Laser Surg
2018633, 83012636
Dual Effect of Photobiomodulation on Melasma: Downregulation of Hyperpigmentation and Enhanced Solar Resistanc
Barolet D · J Clin Aesthet Dermatol
201894013.58
Prevention of acute radiodermatitis by photobiomodulation: A randomized, placebo-controlled trial in breast ca
Robijns · Lasers Surg Med
2018808, 905414
Effects of red light on inflammation and skin barrier recovery following acute perturbation. Pilot study resul
Falcone · Photodermatol Photoimmunol Photomed
20186563.61
Preconditioning With Low-Level Laser Irradiation Enhances the Therapeutic Potential of Human Adipose-derived S
Liao · Photochem Photobiol
20186502—
Potential role of S100A8 in skin rejuvenation with the 1064-nm Q-switched Nd:YAG laser.
Qin · Lasers Med Sci
201810640.5—
Red light accelerates the formation of a human dermal equivalent.
Oliveira · J Biomater Appl
201863030—
The Combined Effects of Curcumin Administration and 630 nm LED Phototherapy against DNCB-induced Atopic Dermat
Jekal · Korean J Clin Lab Sci
2017630510
Skin reactions after photodynamic therapy are unaffected by 839 nm photobiomodulation therapy: A randomized, d
Bay · Lasers Surg Med
2017595, 839655
Comparing the effect of diode laser against acyclovir cream for the treatment of herpes labialis
Honarmand · J Clin Exp Dent
20178704.56
Evaluation of scars in children after treatment with low-level laser.
Alsharnoubi · Lasers Med Sci
20176331624
Low-Level Light Therapy with 410 nm Light Emitting Diode Suppresses Collagen Synthesis in Human Keloid Fibrobl
Lee · Ann Dermatol
2017410, 630, 830102
The Efficacy and Safety of 660 nm and 411 to 777 nm Light-Emitting Devices for Treating Wrinkles
Nam · Dermatol Surg
2017411, 660, 7775.1784
A Protective Mechanism of Visible Red Light in Normal Human Dermal Fibroblasts: Enhancement of GADD45A-Mediate
Kim · J Invest Dermatol
201766060—
Effects of low-dose light-emitting-diode therapy in combination with water bath for atopic dermatitis in NC/Ng
Kim · Photodermatol Photoimmunol Photomed
201685010—
A single-blind, dose escalation, phase I study of high-fluence light-emitting diode-red light (LED-RL) on huma
Ho · Trials
2016633160—
Early application of low-level laser may reduce the incidence of postherpetic neuralgia (PHN).
Chen · J Am Acad Dermatol
201663323
Ultra-structural effects of different low-level lasers on normal cultured human melanocytes: an in vitro compa
AlGhamdi · Lasers Med Sci
2016457, 6352—
Photobiomodulation for the management of radiation dermatitis: the DERMIS trial, a pilot study of MLS(®) laser
Censabella · Support Care Cancer
2016808, 90546
Prevention of Thyroidectomy Scars in Asian Adults With Low-Level Light Therapy.
Park · Dermatol Surg
2016590, 830607
Water-filtered near-infrared influences collagen synthesis of keloid-fibroblasts in contrast to normal foreski
Zöller · J Photochem Photobiol B
2016780, 1400360—
S100a8/NF-κB signal pathway is involved in the 800-nm diode laser-induced skin collagen remodeling.
Ren · Lasers Med Sci
2016800204
Skin photorejuvenation effects of light-emitting diodes (LEDs): a comparative study of yellow and red LEDs in
Kim · Clin Exp Dermatol
2016410, 480, 525, 580, 595, 630, 8501—
Non-ablative radiofrequency associated or not with Low Level Laser Therapy on the treatment of facial wrinkles
Pereira · J Cosmet Laser Ther
20166583.8224
Protective effect of infrared-A radiation against damage induced by UVB radiation in the melan-a cell line.
Portantiolo Lettnin · J Photochem Photobiol B
2016760, 14000.8—
An ex vivo study of photobiostimulation in the treatment of skin pathologies.
de Jesus · J Biophotonics
20166700.07—
Resveratrol Prevents High Fluence Red Light-Emitting Diode Reactive Oxygen Species-Mediated Photoinhibition of
Mamalis · PLoS One
2015633480—
A Novel Treatment of Herpes Zoster Pain With Pulsed Laser Irradiation.
Fan & Wang · Dermatol Surg
201510640.81
Effective photoprotection of human skin against infrared A radiation by topically applied antioxidants: result
Grether-Beck · Photochem Photobiol
2015760360—
Low to moderate doses of infrared A irradiation impair extracellular matrix homeostasis of the skin and contri
Robert · Skin Pharmacol Physiol
2015600, 140020—
Light-emitting diode-generated red light inhibits keloid fibroblast proliferation.
Mamalis & Jagdeo · Dermatol Surg
2015633240—
Continuous irradiation with a 633-nm light-emitting diode exerts an anti-aging effect on human skin cells.
Kim · Int J Mol Med
20156330.43—
Histopathological Analysis of UVB and IR Interaction in Rat Skin.
Gonzalez · Photochem Photobiol
20156001080—
Red Light Modulates Ultraviolet-Induced Gene Expression in the Epidermis of Hairless Mice.
Myakishev-Rempel · Photomed Laser Surg
20156702.53
Inflammatory Cytokine Expression and Sebum Production after Exposure of Cultured Human Sebocytes to Ultraviole
Lee · Ann Dermatol
2014650, 8302—
Effect of red and near-infrared wavelengths on low-level laser (light) therapy-induced healing of partial-thic
Gupta · Lasers Med Sci
2014635, 730, 810, 98047
Treatment of onychomycosis using the 1 064 nm Nd:YAG laser: a clinical pilot study.
Hees · J Dtsch Dermatol Ges
20141064502
Depressed Facial Scars Successfully Treated with Autologous Platelet-Rich Plasma and Light-Emitting Diode Phot
Oh · Ann Dermatol
2014830728
A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction,
Wunsch & Matuschka · Photomed Laser Surg
2014570, 611, 650, 850930
Activated ERK/FOXM1 pathway by low-power laser irradiation inhibits UVB-induced senescence through down-regula
Ling · J Cell Physiol
20146331—
Ultrastructure and light microscope analysis of intact skin after a varying number of low level laser irradiat
Iyomasa · Biomed Res Int
2014780203
Efficacy of red light alone and methyl-aminolaevulinate-photodynamic therapy for the treatment of mild and mod
Pinto · Indian J Dermatol Venereol Leprol
2013635372
The clinical and histological effect of home-use, combination blue-red LED phototherapy for mild-to-moderate a
Kwon · Br J Dermatol
2013420, 6600.914
Postherpetic neuralgia: case study of class 4 laser therapy intervention.
Knapp DJ · Clin J Pain
2013810, 9803.58
In vivo and in vitro analysis of low level light therapy: a useful therapeutic approach for sensitive skin
Choi · Lasers Med Sci
20134807.22
Comparison of Red and Infrared Low-level Laser Therapy in the Treatment of Acne Vulgaris.
Aziz-Jalali · Indian J Dermatol
2012630, 8901212
Antiphotoaging effects of light-emitting diode irradiation on narrow-band ultraviolet B-exposed cultured human
Tian · Dermatol Surg
2012630, 660, 830, 8501—
The effect of 670-nm low laser therapy on herpes simplex type 1.
Muñoz Sanchez · Photomed Laser Surg
20126702.041
Prevention of recurrent herpes labialis outbreaks through low-intensity laser therapy: a clinical protocol wit
Eduardo Cde · Lasers Med Sci
20127808.7510
Light-emitting diodes at 830 and 850 nm inhibit melanin synthesis in vitro.
Kim · Acta Derm Venereol
2012830, 8501—
Efficacy of blue light vs. red light in the treatment of psoriasis: a double-blind, randomized comparative stu
Kleinpenning · J Eur Acad Dermatol Venereol
2012420, 63012012
Recurrent herpes simplex infections: laser therapy as a potential tool for long-term successful treatment.
Ferreira · Rev Soc Bras Med Trop
2011660304
The 800-nm diode laser irradiation induces skin collagen synthesis by stimulating TGF-β/Smad signaling pathway
Dang · Lasers Med Sci
2011800204
Noninvasive cutaneous blood flow as a response predictor for visible light therapy on segmental vitiligo: a pr
Yu · Br J Dermatol
20116353—
Radiant near infrared light emitting Diode exposure as skin preparation to enhance photodynamic therapy inflam
Barolet & Boucher · Lasers Surg Med
2010970721
Effect of laser phototherapy on recurring herpes labialis prevention: an in vivo study.
de Carvalho · Lasers Med Sci
2010780310
Low- and high-intensity lasers in the treatment of herpes simplex virus 1 infection.
Bello-Silva · Photomed Laser Surg
20106603.8—
Low reactive level laser therapy in the treatment of post herpetic neuralgia
Sasaki · Laser Ther
20108304513
Combination 830-nm and 633-nm light-emitting diode phototherapy shows promise in the treatment of recalcitrant
Ablon G · Photomed Laser Surg
2010633, 8301262
Prophylactic low-level light therapy for the treatment of hypertrophic scars and keloids: a case series.
Barolet & Boucher · Lasers Surg Med
20108052730
Effects of diode laser therapy on the acellular dermal matrix.
Soares · Cell Tissue Bank
20096854—
A study to determine the effect of combination blue (415 nm) and near-infrared (830 nm) light-emitting diode (
Sadick N · J Cosmet Laser Ther
2009415, 830488
Single low-dose red light is as efficacious as methyl-aminolevulinate--photodynamic therapy for treatment of a
Hörfelt · Acta Derm Venereol
2009635151
Improvement of postfractional laser erythema with light-emitting diode photomodulation.
Alster & Wanitphakdeedecha · Dermatol Surg
20095900.11
Regulation of skin collagen metabolism in vitro using a pulsed 660 nm LED light source: clinical correlation w
Barolet · J Invest Dermatol
2009660412
Mirror, mirror on the wall: placebo effects that exist only in the eye of the beholder
Kelley · J Eval Clin Pract
20095880.18
In the eye of the beholder--skin rejuvenation using a light-emitting diode photomodulation device.
Boulos · Dermatol Surg
20095880.18
Green tea and red light--a powerful duo in skin rejuvenation.
Sommer & Zhu · Photomed Laser Surg
200967049
Low-energy helium-neon laser induces melanocyte proliferation via interaction with type IV collagen: visible l
Lan · Br J Dermatol
20096331—
Non-invasive diagnostic evaluation of phototherapeutic effects of red light phototherapy of acne vulgaris.
Zane · Photodermatol Photoimmunol Photomed
2008600, 750208
A study to determine the efficacy of a novel handheld light-emitting diode device in the treatment of photoage
Sadick NS · J Cosmet Dermatol
2008633, 8301264
LED photoprevention: reduced MED response following multiple LED exposures.
Barolet & Boucher · Lasers Surg Med
200866055
Low-energy helium-neon laser therapy induces repigmentation and improves the abnormalities of cutaneous microc
Wu · Kaohsiung J Med Sci
2008633317
Red light phototherapy alone is effective for acne vulgaris: randomized, single-blinded clinical trial.
Na & Suh · Dermatol Surg
2007635, 6700.185112
Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV.
Lee · Lasers Surg Med
2007415, 633488
Low-level-laser therapy as an alternative treatment for primary herpes simplex infection: a case report.
Navarro · J Clin Pediatr Dent
20076607.52
Treatment of radiation-induced dermatitis with light-emitting diode (LED) photomodulation.
DeLand · Lasers Surg Med
20075900.1533
Clinical experience with 630 nm light-emitting diode (LED) photomodulation for sun-induced aging or environmen
Taniguchi · Laser Ther
20076302.9310
The use of light-emitting diode therapy in the treatment of photoaged skin.
Baez & Reilly · J Cosmet Laser Ther
2007633, 8301259
A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED photothera
Lee · J Photochem Photobiol B
2007633, 830668
Light-emitting diode phototherapy at 630 +/- 3 nm increases local levels of skin-homing T-cells in human subje
Takezaki · J Nippon Med Sch
2006630948
Combined visible light and infrared light-emitting diode (LED) therapy enhances wound healing after laser abla
Tralles · Medical Laser Application
2006633, 830984
Red light-emitting diode (LED) therapy accelerates wound healing post-blepharoplasty and periocular laser abla
Trelles & Allones · J Cosmet Laser Ther
2006633964
Use of nonthermal blue (405- to 420-nm) and near-infrared light (850- to 900-nm) dual-wavelength system in com
Fournier · Dermatol Surg
2006405, 420, 850, 900608
Comparison of biophysical properties of skin measured by using non-invasive techniques in the KM mice followin
Dang · Skin Res Technol
2006595, 1064, 1320124
Infrared radiation induces the p53 signaling pathway: role in infrared prevention of ultraviolet B toxicity.
Frank · Exp Dermatol
2006400162—
Light‐emitting diode 415 nm in the treatment of inflammatory acne: An open‐label, multicentric, pilot investig
Tremblay · J Cosmet Laser Ther
2005415482
An open study to determine the efficacy of blue light in the treatment of mild to moderate acne
Morton · J Dermatolog Treat
2005409, 419488
A single-blinded randomised controlled study to determine the efficacy of Omnilux Revive facial treatment in s
Bhat · Lasers Med Sci
2005633969
Clinical trial of a novel non-thermal LED array for reversal of photoaging: clinical, histologic, and surface
Weiss · Lasers Surg Med
20055900.18
Ultrastructural observations of human skin following irradiation with visible red light-emitting diodes (leds)
Takezaki · Laser Ther
2005633948
A study to determine the efficacy of combination LED light therapy (633 nm and 830 nm) in facial skin rejuvena
Russell · J Cosmet Laser Ther
2005633, 8301253
Topical aminolaevulinic acid-photodynamic therapy for the treatment of acne vulgaris: a study of clinical effi
Pollock · Br J Dermatol
2004635153
Blue light phototherapy in the treatment of acne
Tzung · Photodermatol Photoimmunol Photomed
2004420408
Low Level Laser Therapy--a conservative approach to the burn scar?
Gaida · Burns
2004670416
The effect of 880 nm low level laser energy on human fibroblast cell numbers: a possible role in hypertrophic
Webb & Dyson · J Photochem Photobiol B
20038802.4—
Helium-neon laser irradiation stimulates migration and proliferation in melanocytes and induces repigmentation
Yu · J Invest Dermatol
2003633320
Low intensity laser irradiation in the treatment of recalcitrant radiation ulcers in patients with breast canc
Schindl · Photodermatol Photoimmunol Photomed
2000633305
Low-intensity laser therapy is an effective treatment for recurrent herpes simplex infection. Results from a r
Schindl & Neumann · J Invest Dermatol
1999690482
Clinical application of helium neon (632 nm) plus infrared diode laser GaAIAs (830 nm) and CO2laser in treatme
Nicolopoulos · The Foot
1999633, 83022
Increased dermal angiogenesis after low-intensity laser therapy for a chronic radiation ulcer determined by a
Schindl · J Am Acad Dermatol.
1999633307
Stimulatory effect of 660 nm low level laser energy on hypertrophic scar-derived fibroblasts: possible mechani
Webb · Lasers Surg Med
19986602.4—

Showing 150 of 157 dosed studies in this category.

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