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686 studies · 181 with full dosimetry

Brain and cognition research

Transcranial photobiomodulation research.

Sorted newest first. The dose column is what the study actually delivered, which is the number to compare a device against. Rows without a recorded dose are excluded here because they cannot be matched to a protocol.

StudyYearλ nmDose J/cm²Sessions
Transcranial photobiomodulation improves prefrontal oxygenation and impulse control in adults with ADHD: a ran
Salehpour · BMC Psychiatry
20261064601
Frequency-specific photobiomodulation at theta and gamma enhances cognitive networks and mitigates age-related
Arias · Geroscience
2026810335
A multimodal evaluation of transcranial photobiomodulation in mild cognitive impairment: Cognitive, metabolic,
Rashidi-Ranjbar · J Alzheimers Dis
20268104536
Transcranial 810 nm Pulsed Photobiomodulation Improves Learning and Reduces Aβ42 Burden in APP/PS1 Mouse Model
Zhang · Photobiomodul Photomed Laser Surg
202681013.542
Effects of transcranial photobiomodulation on anxiety-like behavior and spatial learning in adult and old fema
García-Castro · Physiol Behav
20268102012
Photobiomodulation restores blood-brain barrier integrity after hypoxia via endothelial von Willebrand factor
Domocos · J Physiol
2026635, 810, 904, 106433.53
Transcranial photobiomodulation ameliorates hypobaric hypoxia-induced spatial cognitive dysfunction by enhanci
Cao · J Photochem Photobiol B
202610644—
Enhanced combined effect of thymoquinone and transcranial photobiomodulation on cerebral ischemia-induced inju
Jaz · Metab Brain Dis
202681030.63
The effectiveness of Transcranial Photobiomodulation therapy (tPBM) on reducing anxiety, depression, and opioi
Helali · BMC Psychiatry
2025810609
Self-assembly and 3D Bioprinting of Neurospheres and Evaluation of Caffeine and Photobiomodulation Effects in
Salles · Stem Cell Rev Rep
20256603—
Photobiomodulation modulates mitochondrial energy metabolism and ameliorates neurological damage in an APP/PS1
Chen · Alzheimers Res Ther
202580836
Improved cognitive function, efficiency, saccadic eye movement, and depressive symptoms in mild cognitive impa
Lee · J Alzheimers Dis
202581010.815
Neurometabolite Changes After Transcranial Photobiomodulation in Major Depressive Disorder: A Randomized Contr
Coelho · J Clin Med
2025808601
Augmenting Internet-Based Cognitive Behavioral Therapy for Major Depressive Disorder With Transcranial Infrare
Barrett · Biol Psychiatry Glob Open Sci
2025106460—
Wearable, self-administered transcranial photobiomodulation for major depressive disorder and sleep: A randomi
Guu · J Affect Disord
2025850221
Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Seizure Frequency and Brain Met
Cardoso · Mol Neurobiol
2025810535.730
Age as a limiting factor for effectiveness of photostimulation of brain drainage and cognitive functions
Terskov · Front Optoelectron
2025105030—
Improvements in Resting-State Functional Connectivity of the Cerebellum after Transcranial Photobiomodulation
Keleher · Photobiomodul Photomed Laser Surg
2025810, 1060240—
Photobiomodulation Promotes Early Recovery of Olfactory Function and Modulates Neuroprotective Gene Expression
Shalaby · Transl Stroke Res
2025808406
Transcranial Photobiomodulation Therapy as an Intervention for Opioid Cravings and Depression: A Pilot Cohort
Flora & Huffer · Photobiomodul Photomed Laser Surg
2024810172.8—
Neuroprotective Potential of Photobiomodulation Therapy: Mitigating Amyloid-Beta Accumulation and Modulating A
Thammasart · Photobiomodul Photomed Laser Surg
2024660, 8103—
Near-infrared light stimulation regulates neural oscillation and memory behavior of mice with Alzheimer's dise
Zhang · Front Neurosci
202410704.5—
Transcranial photobiomodulation increases intrinsic brain activity within irradiated areas in early Alzheimer'
Gaggi · Brain Stimul
2024808185.31
Photobiomodulation's Potential as a Non-Invasive Therapy for Alzheimer's disease and Minimal Cognitive Impairm
Razzaghi · Photodiagnosis Photodyn Ther
2024810756
Dose Response of Transcranial Photobiomodulation on Cognitive Efficiency in Healthy Older Adults: A Task-Relat
Lee & Chan · J Alzheimers Dis
202481010.81
Activation of testosterone-androgen receptor mediates cerebrovascular protection by photobiomodulation treatme
Feng · CNS Neurosci Ther
2024808427
Mechanisms of phototherapy of Alzheimer's disease during sleep and wakefulness: the role of the meningeal lymp
Semyachkina-Glushkovskaya · Front Optoelectron
202310505007
Exosomes Derived from M2 Microglial Cells Modulated by 1070-nm Light Improve Cognition in an Alzheimer's Disea
Chen · Adv Sci (Weinh)
202310702—
Attenuation Aβ1-42-induced neurotoxicity in neuronal cell by 660nm and 810nm LED light irradiation
Thammasart · PLoS One
2023660, 8101—
Effects of 660-nm LED photobiomodulation on drebrin expression pattern and astrocyte migration
Yoon · Sci Rep
20236606—
Efficacy of Laser Acupuncture for Children With Autism Spectrum Disorder: Clinical, Molecular, and Biochemical
Elsheikh · Pediatr Neurol
2023850312
Prefrontal photobiomodulation produces beneficial mitochondrial and oxygenation effects in older adults with b
O'Donnell · Front Neurosci
20231064751
Effects of intravascular photobiomodulation on cognitive impairment and crossed cerebellar diaschisis in patie
Lin · Lasers Med Sci
2023633459210
Effect of low-level laser therapy on quadriceps and foot muscle fatigue in children with spastic diplegia: a r
Abdelhalim · Lasers Med Sci
2023810164.855
Transcranial photobiomodulation mitigates learning and memory impairments induced by hindlimb unloading in a m
Kazmi · Brain Res
20238108—
Photobiomodulation improves frontal lobe cognitive functions and mental health of older adults with non-amnest
Cheung · Front Psychol
20238102118
Photobiomodulation may enhance cognitive efficiency in older adults: a functional near-infrared spectroscopy s
Lee & Chan · Front Aging Neurosci
202381071
Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibitin
Hong · Cell Biosci
2023825, 85015.21
Photostimulation of brain lymphatics in male newborn and adult rodents for therapy of intraventricular hemorrh
Li · Nat Commun
2023126797
Transcranial photobiomodulation ameliorates midbrain and striatum neurochemical impairments and behavioral def
Mohammed · Photochem Photobiol Sci
202383015.2814
Transcranial near-infrared laser improves postoperative neurocognitive disorder in aged mice via SIRT3/AMPK/Nr
Zhong · Front Neurosci
2023810183
The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer's Disease Mouse Model
Buendía · Brain Sci
202263043.5—
Promoted CD4+ T cell-derived IFN-γ/IL-10 by photobiomodulation therapy modulates neurogenesis to ameliorate co
Wu · J Neuroinflammation
2022635101
A Randomized, Double-Blind, and Sham-Controlled Trial of an Innovative Brain-Gut Photobiomodulation Therapy: S
Blivet · J Alzheimers Dis
2022660, 85019.140
Therapeutic Effects of Low-Level Laser Therapy on Cognitive Symptoms of Patients with Dementia: A Double-Blind
Kheradmand · Photobiomodul Photomed Laser Surg
2022630, 81056.56
Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechani
Stepanov · Alzheimers Res Ther
2022808101
Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model
Yang · Theranostics
2022808423
Photobiomodulation Attenuated Cognitive Dysfunction and Neuroinflammation in a Prenatal Valproic Acid-Induced
Kim · Int J Mol Sci
2022830423
Transcranial Infrared Laser Stimulation for the Treatment of Traumatic Brain Injury: A Case Series
Rindner · J Lasers Med Sci
202210641208
40 Hz Blue LED Relieves the Gamma Oscillations Changes Caused by Traumatic Brain Injury in Rat
Yang · Front Neurol
2022473406
The effect of transcranial photobiomodulation on cognitive function and attentional performance of older women
Papi · Prz Menopauzalny
202285042.755
Very Low-Level Transcranial Photobiomodulation for Major Depressive Disorder: The ELATED-3 Multicenter, Random
Iosifescu · J Clin Psychiatry
202283065.812
Neuromodulation of brain topography and network topology by prefrontal transcranial photobiomodulation
Shahdadian · J Neural Eng
202210641201
Photobiomodulation regulates adult neurogenesis in the hippocampus in a status epilepticus animal model
Hong · Sci Rep
2022830361
Transcranial photobiomodulation (808 nm) attenuates pentylenetetrazole-induced seizures by suppressing hippoca
Tsai · Neurophotonics
2022808133.31
No Effects of Photobiomodulation on Prefrontal Cortex and Hippocampal Cytochrome C Oxidase Activity and Expres
Gutiérrez-Menéndez · Front Neurosci
202281046.55
Photobiomodulation at 830 nm Reduced Nitrite Production by Peripheral Blood Mononuclear Cells Isolated from Mu
Tolentino · Photobiomodul Photomed Laser Surg
202283010—
Effects of intravascular photobiomodulation on motor deficits and brain perfusion images in intractable myasth
Lan · World J Clin Cases
2022633642910
Near-infrared light reduces glia activation and modulates neuroinflammation in the brains of diet-induced obes
Saieva & Taglialatela · Sci Rep
2022670420
Effect of low-level laser therapy (LLLT) on cognitive impairment among patients with chronic schizophrenia: a
Kheradmand · Lasers Med Sci
2022630, 8101446
Intravascular Laser Irradiation of Blood Improves Functional Independence in Subacute Post-Stroke Patients: A
Lai · Photobiomodul Photomed Laser Surg
2022633642910
An Effective and Safe Novel Treatment of Opioid Use Disorder: Unilateral Transcranial Photobiomodulation
Schiffer · Front Psychiatry
2021810608
Unilateral transcranial photobiomodulation for opioid addiction in a clinical practice: A clinical overview an
Schiffer F · J Psychiatr Res
202181060—
Effect of transcranial near-infrared photobiomodulation on cognitive outcomes in D-galactose/AlCl 3 induced br
Hosseini · Lasers Med Sci
20218108—
Transcranial Laser Photobiomodulation Improves Intracellular Signaling Linked to Cell Survival, Memory and Glu
Cardoso · Front Cell Neurosci
2021810535.758
Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer's disease m
Tao · Light Sci Appl
202110704.560
Photoactivation of TGFβ/SMAD signaling pathway ameliorates adult hippocampal neurogenesis in Alzheimer's disea
Wu · Stem Cell Res Ther
2021635230
Night Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer's
Semyachkina-Glushkovskaya · Cells
2021126799
Transcranial Photobiomodulation of Clearance of Beta-Amyloid from the Mouse Brain: Effects on the Meningeal Ly
Semyachkina-Glushkovskaya · Adv Exp Med Biol
20211267329
Pilot Study on Dose-Dependent Effects of Transcranial Photobiomodulation on Brain Electrical Oscillations: A P
Spera · J Alzheimers Dis
202183065.81
Photobiomodulation suppresses JNK3 by activation of ERK/MKP7 to attenuate AMPA receptor endocytosis in Alzheim
Shen · Aging Cell
2021635630
Gut flora-targeted photobiomodulation therapy improves senile dementia in an Aß-induced Alzheimer's disease an
Chen · J Photochem Photobiol B
2021630, 730, 850100—
Transcranial Infrared Laser Stimulation Improves Cognition in Older Bipolar Patients: Proof of Concept Study
O'Donnell · J Geriatr Psychiatry Neurol
20211064755
Effect of NIR light on the permeability of the blood-brain barriers in in vitro models
Zhou · Biomed Opt Express
20218080.3—
Effects of intravascular laser phototherapy on delayed neurological sequelae after carbon monoxide intoxicatio
Liu · World J Clin Cases
2021633257130
Photobiomodulation Enhances Memory Processing in Older Adults with Mild Cognitive Impairment: A Functional Nea
Chan · J Alzheimers Dis
202181071
Photoneuromodulation makes a difficult cognitive task less arduous
Chan · Sci Rep
202181071
Photobiomodulation effects on active brain networks during a spatial memory task
Gutiérrez-Menéndez · Physiol Behav
2021106420—
Improved Spatial Memory And Neuroinflammatory Profile Changes in Aged Rats Submitted to Photobiomodulation The
Cardoso · Cell Mol Neurobiol
2021810535.7—
Synergistic effects of combined therapy with transcranial photobiomodulation and enriched environment on depre
Farazi · Lasers Med Sci
20218108—
Photobiomodulation Therapy Ameliorates Glutamatergic Dysfunction in Mice with Chronic Unpredictable Mild Stres
Zhang · Oxid Med Cell Longev
20216356—
Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Brain Metabolomics of Young and
Cardoso · Mol Neurobil
2021810107.14—
Near-Infrared Light Reduces Glia Activation and Modulates Neuroinflammation in Brain of Diet-Induced Obese Mic
Saieva S · DISSERTATION [University of Texas]
20216704—
Photobiomodulation Promotes Hippocampal CA1 NSC Differentiation Toward Neurons and Facilitates Cognitive Funct
Guo · Front Cell Neurosci
20218080.8—
NIR Laser Photobiomodulation Induces Neuroprotection in an In Vitro Model of Cerebral Hypoxia/Ischemia
Gerace · Mol Neurobiol
2021808, 9053.71—
Transcranial low-level laser therapy in an in vivo model of stroke: Relevance to the brain infarct, microglia
Vogel · J Biophotonics
2021780103
A Novel Treatment of Opioid Cravings With an Effect Size of .73 for Unilateral Transcranial Photobiomodulation
Schiffer · Front Psychiatry
2020810601
Photostimulation of Extravasation of Beta-Amyloid through the Model of Blood-Brain Barrier
Zinchenko · Electronics
202012679—
Effect of Transcranial Low-Level Light Therapy vs Sham Therapy Among Patients With Moderate Traumatic Brain In
Longo · JAMA Netw Open
2020810433
Effect of Infrared Low-Intensity Laser Irradiation on Lipid Peroxidation Under Conditions of Experimental Circ
Shurygina · Bull Exp Biol Med
20208900.3—
Study of transcranial photobiomodulation at 945-nm wavelength: anxiety and depression.
Kerppers · Lasers Med Sci
20209459.3530
Repetitive transcranial photobiomodulation but not long-term omega-3 intake reduces epileptiform discharges in
Vogel · J Biophotonics
20207801024
Transcranial photobiomodulation attenuates pentylenetetrazole-induced status epilepticus in peripubertal rats.
Tsai · J Biophotonics
2020808133.31
Pilot study of transcranial photobiomodulation of lymphatic clearance of beta-amyloid from the mouse brain: br
Zinchenko · Biomed Opt Express
20191267325
Transcranial Photobiomodulation with Near-Infrared Light for Generalized Anxiety Disorder: A Pilot Study.
Maiello · Photobiomodul Photomed Laser Surg
2019830368
Transcranial Photobiomodulation to Augment Lithium in Bipolar-I Disorder.
Mannu · Photobiomodul Photomed Laser Surg
2019830408
Transcranial Photobiomodulation Therapy in the Cognitive Rehabilitation of Patients with Cranioencephalic Trau
Carneiro · Photobiomodul Photomed Laser Surg
20196303.743
Photobiomodulation preconditioning prevents cognitive impairment in a neonatal rat model of hypoxia-ischemia.
Yang · J Biophotonics
201980812—
Cognitive Enhancement by Transcranial Photobiomodulation Is Associated With Cerebrovascular Oxygenation of the
Holmes · Front Neurosci
201910641201
Near-infrared photobiomodulation combined with coenzyme Q10 for depression in a mouse model of restraint stres
Salehpour · Brain Res Bull
201981033.35
Transcranial photobiomodulation prevents anxiety and depression via changing serotonin and nitric oxide levels
Eshaghi · Lasers Surg Med
201981049
Transcranial Photobiomodulation for Down Syndrome.
Mannu · Photobiomodul Photomed Laser Surg
2019830408
Transcranial photobiomodulation with 1064-nm laser modulates brain electroencephalogram rhythms.
Wang · Neurophotonics
201910641071
Transcranial near-infrared photobiomodulation could modulate brain electrophysiological features and attention
Jahan · Lasers Med Sci
2019850601
Pulsed Near Infrared Transcranial and Intranasal Photobiomodulation Significantly Modulates Neural Oscillation
Zomorrodi · Sci Rep
20198102401
Short-term Effects of Transcranial Near-Infrared Photobiomodulation on Motor Performance in Healthy Human Subj
Fekri · J Lasers Med Sci
2019808601
Effect of Photobiomodulation in Rescuing Lipopolysaccharide-Induced Dopaminergic Cell Loss in the Male Sprague
O'Brien & Austin · Biomolecules
20196753.59413
Photobiomodulation in Parkinson's disease: A randomized controlled trial
Santos · Brain Stimul
2019670818
Pre-conditioning with remote photobiomodulation modulates the brain transcriptome and protects against MPTP in
Ganeshan · Neuroscience
201967042
Effects of transcranial photobiomodulation and methylene blue on biochemical and behavioral profiles in mice s
Meynaghizadeh-Zargar · Lasers Med Sci
20198108—
Light-Emitting Diode Photobiomodulation After Cerebral Ischemia.
Argibay · Front Neurol
201983018—
Study of transcranial therapy 904 nm in experimental model of stroke.
de Jesus Fonseca · Lasers Med Sci
20199047—
Pulsed Transcranial Red/Near-Infrared Light Therapy Using Light-Emitting Diodes Improves Cerebral Blood Flow a
Hipskind · Photomed Laser Surg
2018629, 8507.718
Effects of transcranial LED therapy on the cognitive rehabilitation for diffuse axonal injury due to severe ac
Santos · Trials
20186271018
A Protocol for Transcranial Photobiomodulation Therapy in Mice.
Salehpour · J Vis Exp
201866099.914
Photobiomodulation improves the frontal cognitive function of older adults.
Chan · Int J Geriatr Psychiatry
2018633, 870201
Light-Emitting Diode (LED) Therapy Attenuates Neurotoxicity of Methanol-Induced Memory Impairment and Apoptosi
Ghanbari · CNS Neurol Disord Drug Targets
2018670428
Transcranial Photobiomodulation for the Treatment of Major Depressive Disorder. The ELATED-2 Pilot Trial.
Cassano · Photomed Laser Surg
201882365.216
A case control series for the effect of photobiomodulation in patients with low back pain and concurrent depre
Gabel CP · Laser Ther
2018660, 8503—
Low-level laser therapy modulates demyelination in mice.
Duarte · J Photochem Photobiol B
2018808366
Transcranial LED therapy on amyloid-β toxin 25-35 in the hippocampal region of rats.
da Luz Eltchechem · Lasers Med Sci
2017627721
Low-level Laser Therapy for Beta-Amyloid Toxicity in Rat Hippocampus
Lu · Neurobiol Aging
2017808155
Transcranial low-level laser therapy improves brain mitochondrial function and cognitive impairment in D-galac
Salehpour · Neurobiol Aging
2017660, 8104—
Improving executive function using transcranial infrared laser stimulation.
Blanco · J Neuropsychol
20171064601
Acute Effects of Near Infrared Light Therapy on Brain State in Healthy Subjects as Quantified by qEEG Measures
Grover · Photomed Laser Surg
2017903201
Photoactivation of ERK/CREB/VMAT2 pathway attenuates MPP +-induced neuronal injury in a cellular model of Park
Gu · Cell Signal
20176331—
Pretreatment with light-emitting diode therapy reduces ischemic brain injury in mice through endothelial nitri
Lee · Biochem Biophys Res Commun
201761024
Low-level light emitting diode (LED) therapy suppresses inflammasome-mediated brain damage in experimental isc
Lee · J Biophotonics
201761026
Low-Level Laser Therapy to the Bone Marrow Ameliorates Neurodegenerative Disease Progression in a Mouse Model
Oron · Photomed Laser Surg
201680816
Repeated transcranial low-level laser therapy for traumatic brain injury in mice: biphasic dose response and l
Xuan · J Biophotonics
2016810183
Transcranial infrared laser stimulation improves rule-based, but not information-integration, category learnin
Blanco · Neurobiol Learn Mem
20161064601
Cognitive enhancement by transcranial laser stimulation and acute aerobic exercise.
Hwang · Lasers Med Sci
20161064601
Transcranial Laser Stimulation as Neuroenhancement for Attention Bias Modification in Adults with Elevated Dep
Disner · Brain Stimul
20161064601
Therapeutic effects of 10-HzPulsed wave lasers in rat depression model: A comparison between near-infrared and
Salehpour · Lasers Surg Med
2016630, 8101.18—
Low-level laser therapy ameliorates disease progression in a mouse model of multiple sclerosis.
Gonçalves · Autoimmunity
2016660, 9041030
Near-infrared light (670 nm) reduces MPTP-induced parkinsonism within a broad therapeutic time window.
Reinhart · Exp Brain Res
20166700.54
Effects of Light Emitting Diode and Low-intensity Light on the immunological process in a model of Parkinson's
Salgado · Med Res Arch
2016627, 63047
Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia.
Purushothuman · Neurosci Lett
2015670420
Low-level laser therapy for traumatic brain injury in mice increases brain derived neurotrophic factor (BDNF)
Xuan · J Biophotonics
2015810361
Treatments for traumatic brain injury with emphasis on transcranial near-infrared laser phototherapy.
Morries · Neuropsychiatr Dis Treat
2015810, 9805510
Low-level light in combination with metabolic modulators for effective therapy of injured brain.
Dong · J Cereb Blood Flow Metab
201581036—
The effects of transcranial LED therapy (TCLT) on cerebral blood flow in the elderly women.
Salgado · Lasers Med Sci
2015627108
Role of low-intensity laser therapy on naloxone-precipitated morphine withdrawal signs in mice: is nitric oxid
Ojaghi · Lasers Med Sci
201483012.5—
Photobiomodulation with near infrared light mitigates Alzheimer's disease-related pathology in cerebral cortex
Purushothuman · Alzheimers Res Ther
2014670420
Transcranial low-level laser therapy enhances learning, memory, and neuroprogenitor cells after traumatic brai
Xuan · J Biomed Opt
2014810181
Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode tr
Naeser · J Neurotrauma
2014633, 8701318
Indirect application of near infrared light induces neuroprotection in a mouse model of parkinsonism – An absc
Johnstone · Neuroscience
20146704—
Low-level laser therapy rescues dendrite atrophy via upregulating BDNF expression: implications for Alzheimer'
Meng · J Neurosci
20136330.5—
Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans.
Barrett & Gonzalez-Lima · Neuroscience
20131064601
Effect of low-level laser stimulation on EEG power in normal subjects with closed eyes.
Wu & Chang · Evid Based Complement Alternat Med
2013830201

Showing 150 of 181 dosed studies in this category.

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