🧑 Human 📄 Case series 👥 12 cases ⌛ 6-week treatment and 1-4 week latency until SPECT measurements post-treatment · 2018 · USA (Addison, TX)
Pulsed Transcranial Red/Near-Infrared Light Therapy Using Light-Emitting Diodes Improves Cerebral Blood Flow and Cognitive Function in Veterans with Chronic Traumatic Brain Injury: A Case Series
Hipskind · Photomed Laser Surg · 2018
The protocol this study used
What the authors concluded
Pulsed tPBMT significantly improved neuropsychological scores in 6 of 15 subscales (40.0%; p < 0.05; two tailed). SPECT analysis showed increase in relative cerebral blood flow (rCBF) in 8 of 12 (66.7%) study participants. Quantitative SPECT analysis revealed a significant increase in rCBF in this subgroup of study participants and a significant difference between pre-treatment and post-treatment
Devices that emit this wavelength
Matched on wavelength within 15nm, since LED bins vary by roughly that much and a tighter match would be false precision. Where we have an irradiance figure, the session length is the time needed to reach this study's dose of 7.7 J/cm² at that intensity.
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Matching a wavelength is not the same as reproducing a trial. Session times assume the device's published irradiance is accurate at the distance it was measured, which on brand-claim figures is often optimistic. Where a device publishes both a peak and an average we use the average, and where it publishes a falloff curve we use the lowest figure, so these times run long rather than short. Clinical protocols also control for spot size, contact and skin type in ways a home device cannot.
Source
Dosimetry extracted by Vladimir Heiskanen in Photobiomodulation (PBM) research - a comprehensive database. Citation resolved against PubMed.