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🐁 Mouse · 2018 · Iran (Tabriz)

A Protocol for Transcranial Photobiomodulation Therapy in Mice.

Salehpour · J Vis Exp · 2018

The protocol this study used

Wavelength
660 nm
Dose
99.9 J/cm²
Sessions
14
Per session
15 sec

What the authors concluded

The results from the Barnes task show an enhancement of the spatial memory in laser-treated aged mice when compared with age-matched controls. Biochemical analysis after laser treatment indicates increased hippocampal ATP levels. We postulate that the enhancement of memory performance is potentially due to an improvement in hippocampal energy metabolism induced by the red laser treatment.

Devices that emit this wavelength

Matched on wavelength within 15nm, since LED bins vary by roughly that much and a tighter match would be false precision. Where we have an irradiance figure, the session length is the time needed to reach this study's dose of 99.9 J/cm² at that intensity.

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MitoPRO 1500+
630 · 660 · 830 · 850 nm
Measured
$1,169
≈ 21 min 46 sec / session
at 76.5 mW/cm²
MitoPRO 1500X
590 · 630 · 660 · 810 · 830 · 850 nm
Measured
$1,299
≈ 31 min 7 sec / session
at 53.5 mW/cm²
PlatinumLED BIOMAX 900
480 · 630 · 660 · 810 · 830 · 850 · 1060 nm
Measured
$1,299
≈ 18 min 26 sec / session
at 90.3 mW/cm²
HoogaHealth PRO1500
660 · 850 nm
Measured
$1,199
≈ 19 min 22 sec / session
at 86 mW/cm²
Joovv Solo 3.0
660 · 850 nm
Measured
$1,499
≈ 28 min 8 sec / session
at 59.2 mW/cm²
LUMEBOX 2.0
660 · 850 nm
Measured
$629
≈ 13 min 19 sec / session
at 125 mW/cm²

Matching a wavelength is not the same as reproducing a trial. Session times assume the device's published irradiance is accurate at the distance it was measured, which on brand-claim figures is often optimistic. Where a device publishes both a peak and an average we use the average, and where it publishes a falloff curve we use the lowest figure, so these times run long rather than short. Clinical protocols also control for spot size, contact and skin type in ways a home device cannot.

Source

PubMed 30507909 →

Dosimetry extracted by Vladimir Heiskanen in Photobiomodulation (PBM) research - a comprehensive database. Citation resolved against PubMed.