Effects of Chronic Photobiomodulation with Transcranial Near-Infrared Laser on Seizure Frequency and Brain Metabolomics of Rats with Pilocarpine-Induced Seizures

What the authors concluded

Our data show that PBM treatment significantly reduced the seizure frequency in rats with pilocarpine-induced seizures. Additionally, significant changes were observed in the metabolomic profiles of the neocortex and hippocampus. In the neocortex, the treatment reduced metabolic pathways associated with excitotoxicity and oxidative stress. In the hippocampus, an increase in phenylalanine concentr

Devices that emit this wavelength

Matched on wavelength within 15nm, since LED bins vary by roughly that much and a tighter match would be false precision. Where we have an irradiance figure, the session length is the time needed to reach this study's dose of 535.7 J/cm² at that intensity.

Matching a wavelength is not the same as reproducing a trial. Session times assume the device's published irradiance is accurate at the distance it was measured, which on brand-claim figures is often optimistic. Where a device publishes both a peak and an average we use the average, and where it publishes a falloff curve we use the lowest figure, so these times run long rather than short. Clinical protocols also control for spot size, contact and skin type in ways a home device cannot.