🧑 Human 📄 Single-arm study 👥 19 participants ⌛ single session (partial/preliminary data) (published as a Correspondence) · 2024 · USA
Transcranial photobiomodulation increases intrinsic brain activity within irradiated areas in early Alzheimer's disease: Potential link with cerebral metabolism
Gaggi · Brain Stimul · 2024
The protocol this study used
What the authors concluded
Effect sizes for the change from baseline fALFF (pre-t-PBM) within the target regions during and post-t-PBM were medium-to-large despite the small sample size. Effect sizes were larger during versus after t-PBM condition, suggesting that targets were engaged more during t-PBM with effects diminishing somewhat after. These results suggest that fALFF could be helpful in investigating varying parame
Devices that emit this wavelength
Matched on wavelength within 15nm, since LED bins vary by roughly that much and a tighter match would be false precision. Where we have an irradiance figure, the session length is the time needed to reach this study's dose of 185.3 J/cm² at that intensity.
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Matching a wavelength is not the same as reproducing a trial. Session times assume the device's published irradiance is accurate at the distance it was measured, which on brand-claim figures is often optimistic. Where a device publishes both a peak and an average we use the average, and where it publishes a falloff curve we use the lowest figure, so these times run long rather than short. Clinical protocols also control for spot size, contact and skin type in ways a home device cannot.
Source
Dosimetry extracted by Vladimir Heiskanen in Photobiomodulation (PBM) research - a comprehensive database. Citation resolved against PubMed.