🐁 Mouse · 2014 · Brazil (Florianópolis)
Light-emitting diode therapy induces analgesia in a mouse model of postoperative pain through activation of peripheral opioid receptors and the L-arginine/nitric oxide pathway.
Cidral-Filho · Lasers Med Sci · 2014
The protocol this study used
What the authors concluded
In conclusion, our results demonstrate, for the first time, that LEDT (950 nm, 80 mW/cm2) induced a dose–response analgesic effect in the model of PI in mice. At the energy density of 9 J/cm2, LEDT presented the most significant results through (1) activation of peripheral opioid receptors which involve, at least in part, the recruitment of opioid-containing leukocytes to the PI site and (2) acti
Devices that emit this wavelength
Matched on wavelength within 15nm, since LED bins vary by roughly that much and a tighter match would be false precision. Where we have an irradiance figure, the session length is the time needed to reach this study's dose of 1 J/cm² at that intensity.
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Matching a wavelength is not the same as reproducing a trial. Session times assume the device's published irradiance is accurate at the distance it was measured, which on brand-claim figures is often optimistic. Where a device publishes both a peak and an average we use the average, and where it publishes a falloff curve we use the lowest figure, so these times run long rather than short. Clinical protocols also control for spot size, contact and skin type in ways a home device cannot.
Source
Dosimetry extracted by Vladimir Heiskanen in Photobiomodulation (PBM) research - a comprehensive database. Citation resolved against PubMed.