🧑 Human ⚔ Comparison study, randomized, double-blind 👥 (?) ⌛ 10 weeks · 2025 · Brazil (Parnaíba)
Dose-response and efficacy of 660-nanometer low-level laser therapy in healing diabetic foot ulcers: a randomized, double-blind, clinical trial
Miranda · Lasers Med Sci · 2025
The protocol this study used
What the authors concluded
There was no statistically significant difference in the ulcer reduction rate between the groups after 5 (p = 0.2582) and 10 weeks (p = 0.1164). Within each group, a significant reduction in ulcer size was observed over time (p < 0.0001). Regardless of the wavelength, all patients experienced a 50% reduction in the wound area when applying an energy density of 8-12 J/cm2. However, the red g
Devices that emit this wavelength
Matched on wavelength within 15nm, since LED bins vary by roughly that much and a tighter match would be false precision. Where we have an irradiance figure, the session length is the time needed to reach this study's dose of 4 J/cm² at that intensity.
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Matching a wavelength is not the same as reproducing a trial. Session times assume the device's published irradiance is accurate at the distance it was measured, which on brand-claim figures is often optimistic. Where a device publishes both a peak and an average we use the average, and where it publishes a falloff curve we use the lowest figure, so these times run long rather than short. Clinical protocols also control for spot size, contact and skin type in ways a home device cannot.
Source
Dosimetry extracted by Vladimir Heiskanen in Photobiomodulation (PBM) research - a comprehensive database. Citation resolved against PubMed.